"I started using Thrive about 2 years ago. Today I am in better health and at least as good fitness as I was 20 years ago, and I ascribe much of that to Thrive. I am a 60 year old male. I started taking Thrive when I was in a high stress position and doing a lot of international travel. Today I sleep better, have better muscle tone, my systems all seem to work more efficiently and I have been able to lose weight and keep it off. While Thrive works over time so that you don't necessarily feel the improvement, when I stopped taking it for a short period, I noticed diminished energy during my work day and exercise. I plan to continue taking Thrive for the foreseeable future."
"I have been using Thrive regularly for well over a year now. In that time, bladder function has improved dramatically providing daytime freedom (no more emergency exits from the dinner table or the freeway) and nighttime comfort (lots more prolonged periods of uninterrupted and restful sleep). I now take long hikes and 90-minute yoga classes, enjoy 3-hour movies from the center of the theater, sit happily in the arena thru entire NBA games. Joint and muscle pain has all but disappeared, so I am able to be much more active (without pain or restriction) for longer, more regular periods of time, have lost weight and kept it off, feel much younger and more vibrant. As I approach my 63rd birthday, I feel I can SUBTRACT the year from my age rather than adding one. One side effect I had not expected is that I sometimes have to pinch myself to remind me of what I felt like before Thrive put this smile on my face, this bounce back in my step."
"I began taking Thrive with the hope it might make some small difference in what had become my existence. Incontinence was a way of life for me, affecting my work and home life to the point that I was at risk of losing my job and had to plan my time around the need to use the restroom every 20-30 minutes day and night, and even more frequently with exertion. Exhaustion was my new "normal." I had been a competitive basketball player but had to give up playing because I couldn't contribute to the game for needing to leave the court so frequently. All that changed with Thrive.
"In short order, I noticed I was going longer between bathroom visits and not getting up as frequently during the night. Sleep improved and I had more energy during the day. Before long, I was contributing again at work and perhaps most importantly, I was able to return to playing the game I love. Playing basketball again provides me with physical, mental, and emotional fitness that makes me better in all aspects of my life and I credit Thrive with giving me back my joyful life."
"My primary passion for the past 37 years, outside of work and my marriage, has been long distance running. I've run at least one marathon and many shorter races in each of those years and have averaged running 50 miles per week. During the past few years, I have seen an appreciable diminishment of both my stamina and my pace, fatiguing more easily and needing to slow my pace to compensate. Since taking Thrive regularly, my race times have improved to those I enjoyed a decade ago and I am able to train more aggressively and recover more quickly."
"I was born into a bad gene pool for heart health. Both my parents died of heart attacks and my younger brother has had 5 heart attacks and multiple stents and bypass surgeries. As a consequence, I am religious about seeing my cardiologist annually. After taking Thrive for about 8 months, it was time for my annual visit and when he reported my test results he said to me, 'I don't know what you've been doing differently, but keep it up, because your test numbers are better now than they were 10 years ago when you first began seeing me!' The only change I had made in my health routine was the addition of Thrive."
Stimulates the production of Ca2+ATPase
critical to normal cellular function
Background: Thrive (tm) is an extraordinary dietary supplement which marries ancient wisdom with modern science to help promote optimal cellular health. Enzymes are proteins built by the body that dramatically increase the efficiency of chemical reactions in all cells in all systems. The ability to build these enzymes declines with age. Thrive invigorates the production of Ca2+ATPase, an enzyme found in every cell in the body, to help restore and maintain cellular and systemic health. This return to dynamic equilibrium provides positive benefits for muscle performance, cardiac health, bladder function, sleep, body discomfort and more.
Jasmine flower, Ginger root, and Green tea have been used for centuries by people all over the world to restore and promote health. Thrive uses the highest grade Jasmonates, Gingerols, and EGCG, and combines them in a proprietary formula with amino acids and d-ribose, important building blocks for proteins and energy production, to create a supplement which supports vibrant aging. When cells are healthy, systems work better. And when systems work better, you Thrive.
By helping promote Ca2+ATPase production and providing important nutrients, Thrive (tm) supports:
Thrive (tm) includes comprehensively researched natural ingredients in a formulation designed to support our body’s production of these essential enzymes to promote optimal health in every system in our bodies.
Directions: Adults take 1 ml (2x) daily, mixed in 6 oz. of water, with or without food. Not intended for children under 18 years of age. Warning: If you are pregnant or lactating, seek the advice of A health professional before using this product. Keep out of reach of children.
Ingredients: EGCG (Green tea extract), D-Ribose, Gingerol (Ginger root extract), Methyl Jasmonate (Jasmine flower extract), L-Arginine, Taurine; inactive ingredients: purified water, vegetable glycerin, citric acid.
Stimulants and Precursors
to Ca2+ATPase Production:
Some Research Citations
Starling AP, Hughes G, East JM, Lee AG. Mechanism of stimulation of the calcium adenosinetriphophatase by jasmone. Biochemistry 1994 Mar 15;33(10):3023-31
Starling AP, East JM, Lee AG. Evidence that the effects of phospholipids on the activity of the Ca(2+)-ATPase do not involve aggregation. Biochem J. 1995 May 15;308 (Pt 1):343-6
Antipenko AY, Spielman AI, Kirchberger MA. Comparison of the effects of phospholamban and jasmone on the calcium pump of cardiac sarcoplasmic reticulum. Evidence for modulation by phospholamban of both Ca2+ affinity and Vmax (Ca) of calcium transport. J Biol Chem. 1997 Jan 31;272(5):2852-60
Joumaa WH, Bouhlel A, Meme W, Leoty C. Methyl jasmonate-induced stimulation of sarcoplasmic reticulum Ca(2+)-ATPase affects contractile responses in rat slow-twitch skeletal muscle. J Pharmacol Exp Ther. 2002 Feb;300(2):638-46
Kobayashi M, Shoji N, Ohizumi Y. Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum. Biochem Biophys Acta. 1987 Sep 18;903(1):96-102
Kobayashi M, Ishida Y, Shoji N, Ohizumi Y. Cardiotonic action of -gingerol, an activator of the Ca++-pumping adenosine triphosphatase of sarcoplasmic reticulum, in guinea pig atrial muscle. J Pharmacol Exp Ther. 1988 Aug;246(2):667-73.
Ohizumi Y, Sasaki S, Shibusawa K, Ishikawa K, Ikemoto F. Stimulation of sarcoplasmic reticulum Ca(2+)-ATPase by gingerol analogues. Biol Pharm Bull. 1996 Oct;19(10):1377-9.
Maier LS, Schwan C, Schillinger W, Minami K, Schütt U, Pieske B. Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium. Cardiovasc Res. 2000 Mar;45(4):913-24.
Dorval V, Dufour M, Leclerc P. Regulation of the phosphotyrosine content of human sperm proteins by intracellular Ca2+: role of Ca2+-adenosine triphosphatases. Biol Reprod. 2002 Nov;67(5):1538-45.
Watanabe M, Shigekawa M. [Physiological functions of endoplasmic and sarcoplasmic reticulum Ca pump and pharmacology of inhibitors of the pump]. Nihon Yakurigaku Zasshi. 1993 Sep;102(3):171-80.
Namekata I, Hamaguchi S, Wakasugi Y, Ohhara M, Hirota Y, Tanaka H. Ellagic acid and gingerol, activators of the sarco-endoplasmic reticulum Ca²⁺-ATPase, ameliorate diabetes mellitus-induced diastolic dysfunction in isolated murine ventricular myocardia. Eur J Pharmacol. 2013 Apr 15;706(1-3):48-55. doi: 10.1016/j.ejphar.2013.02.045. Epub 2013 Mar 13.
Jin YR, Im JH, Park ES, Cho MR, Han XH, Lee JJ, Lim Y, Kim TJ, Yun YP. Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. J Cardiovasc Pharmacol. 2008 Jan;51(1):45-54. doi: 10.1097/FJC.0b013e31815ab4b6.
Devika PT, Mainzen Prince PS. (-)-Epigallocatechin gallate (EGCG) prevents isoprenaline-induced cardiac marker enzymes and membrane-bound ATPases. J Pharm Pharmacol. 2008 Jan;60(1):125-33.
Kargacin ME, Emmett TL, Kargacin GJ. Epigallocatechin-3-gallate has dual, independent effects on the cardiac sarcoplasmic reticulum/endoplasmic reticulum Ca2+ ATPase. J Muscle Res Cell Motil. 2011 Sep;32(2):89-98. doi: 10.1007/s10974-011-9256-7. Epub 2011 Aug 5.
Soler F, Asensio MC, Fernández-Belda F. Inhibition of the intracellular Ca(2+) transporter SERCA (Sarco-Endoplasmic Reticulum Ca(2+)-ATPase) by the natural polyphenol epigallocatechin-3-gallate. J Bioenerg Biomembr. 2012 Oct;44(5):597-605. doi: 10.1007/s10863-012-9462-z. Epub 2012 Aug 1.
Kumar P, Maurya PK. Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans. Adv Pharm Bull. 2014 Oct;4(Suppl 1):443-7. doi: 10.5681/apb.2014.065. Epub 2014 Aug 25.