Stimulates the production of Ca2+ATPase
critical to normal cellular function
Background: Thrive (tm) is an extraordinary dietary supplement which marries ancient wisdom with modern science to help promote optimal cellular health. Enzymes are proteins built by the body that dramatically increase the efficiency of chemical reactions in all cells in all systems. The ability to build these enzymes declines with age. Thrive invigorates the production of Ca2+ATPase, an enzyme found in every cell in the body, to help restore and maintain cellular and systemic health. This return to dynamic equilibrium provides positive benefits for muscle performance, cardiac health, bladder function, sleep, body discomfort and more.
Jasmine flower, Ginger root, and Green tea have been used for centuries by people all over the world to restore and promote health. Thrive uses the highest grade Jasmonates, Gingerols, and EGCG, and combines them in a proprietary formula with amino acids and d-ribose, important building blocks for proteins and energy production, to create a supplement which supports vibrant aging. When cells are healthy, systems work better. And when systems work better, you Thrive.
By helping promote Ca2+ATPase production and providing important nutrients, Thrive (tm) supports:
Thrive (tm) includes comprehensively researched natural ingredients in a formulation designed to support our body’s production of these essential enzymes to promote optimal health in every system in our bodies.
Directions: Adults take 1 ml (2x) daily, mixed in 6 oz. of water, with or without food. Not intended for children under 18 years of age. Warning: If you are pregnant or lactating, seek the advice of A health professional before using this product. Keep out of reach of children.
Ingredients: EGCG (Green tea extract), D-Ribose, Gingerol (Ginger root extract), Methyl Jasmonate (Jasmine flower extract), L-Arginine, Taurine; inactive ingredients: purified water, vegetable glycerin, citric acid.
Stimulants and Precursors
to Ca2+ATPase Production:
Some Research Citations
Starling AP, Hughes G, East JM, Lee AG. Mechanism of stimulation of the calcium adenosinetriphophatase by jasmone. Biochemistry 1994 Mar 15;33(10):3023-31
Starling AP, East JM, Lee AG. Evidence that the effects of phospholipids on the activity of the Ca(2+)-ATPase do not involve aggregation. Biochem J. 1995 May 15;308 (Pt 1):343-6
Antipenko AY, Spielman AI, Kirchberger MA. Comparison of the effects of phospholamban and jasmone on the calcium pump of cardiac sarcoplasmic reticulum. Evidence for modulation by phospholamban of both Ca2+ affinity and Vmax (Ca) of calcium transport. J Biol Chem. 1997 Jan 31;272(5):2852-60
Joumaa WH, Bouhlel A, Meme W, Leoty C. Methyl jasmonate-induced stimulation of sarcoplasmic reticulum Ca(2+)-ATPase affects contractile responses in rat slow-twitch skeletal muscle. J Pharmacol Exp Ther. 2002 Feb;300(2):638-46
Kobayashi M, Shoji N, Ohizumi Y. Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum. Biochem Biophys Acta. 1987 Sep 18;903(1):96-102
Kobayashi M, Ishida Y, Shoji N, Ohizumi Y. Cardiotonic action of -gingerol, an activator of the Ca++-pumping adenosine triphosphatase of sarcoplasmic reticulum, in guinea pig atrial muscle. J Pharmacol Exp Ther. 1988 Aug;246(2):667-73.
Ohizumi Y, Sasaki S, Shibusawa K, Ishikawa K, Ikemoto F. Stimulation of sarcoplasmic reticulum Ca(2+)-ATPase by gingerol analogues. Biol Pharm Bull. 1996 Oct;19(10):1377-9.
Maier LS, Schwan C, Schillinger W, Minami K, Schütt U, Pieske B. Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium. Cardiovasc Res. 2000 Mar;45(4):913-24.
Dorval V, Dufour M, Leclerc P. Regulation of the phosphotyrosine content of human sperm proteins by intracellular Ca2+: role of Ca2+-adenosine triphosphatases. Biol Reprod. 2002 Nov;67(5):1538-45.
Watanabe M, Shigekawa M. [Physiological functions of endoplasmic and sarcoplasmic reticulum Ca pump and pharmacology of inhibitors of the pump]. Nihon Yakurigaku Zasshi. 1993 Sep;102(3):171-80.
Namekata I, Hamaguchi S, Wakasugi Y, Ohhara M, Hirota Y, Tanaka H. Ellagic acid and gingerol, activators of the sarco-endoplasmic reticulum Ca²⁺-ATPase, ameliorate diabetes mellitus-induced diastolic dysfunction in isolated murine ventricular myocardia. Eur J Pharmacol. 2013 Apr 15;706(1-3):48-55. doi: 10.1016/j.ejphar.2013.02.045. Epub 2013 Mar 13.
Jin YR, Im JH, Park ES, Cho MR, Han XH, Lee JJ, Lim Y, Kim TJ, Yun YP. Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. J Cardiovasc Pharmacol. 2008 Jan;51(1):45-54. doi: 10.1097/FJC.0b013e31815ab4b6.
Devika PT, Mainzen Prince PS. (-)-Epigallocatechin gallate (EGCG) prevents isoprenaline-induced cardiac marker enzymes and membrane-bound ATPases. J Pharm Pharmacol. 2008 Jan;60(1):125-33.
Kargacin ME, Emmett TL, Kargacin GJ. Epigallocatechin-3-gallate has dual, independent effects on the cardiac sarcoplasmic reticulum/endoplasmic reticulum Ca2+ ATPase. J Muscle Res Cell Motil. 2011 Sep;32(2):89-98. doi: 10.1007/s10974-011-9256-7. Epub 2011 Aug 5.
Soler F, Asensio MC, Fernández-Belda F. Inhibition of the intracellular Ca(2+) transporter SERCA (Sarco-Endoplasmic Reticulum Ca(2+)-ATPase) by the natural polyphenol epigallocatechin-3-gallate. J Bioenerg Biomembr. 2012 Oct;44(5):597-605. doi: 10.1007/s10863-012-9462-z. Epub 2012 Aug 1.
Kumar P, Maurya PK. Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans. Adv Pharm Bull. 2014 Oct;4(Suppl 1):443-7. doi: 10.5681/apb.2014.065. Epub 2014 Aug 25.