The powerful immune-response
effects of a group of poly-
saccharides ("aloe polymannans")
has created an avalanche of
research, a large American MLM
company that sells off the less
effective, lower weight variety at
hefty markups, and an injectable
version in Florida that produced so
many cancer remissions that medical
authorities had the clinic closed
down. Now we're here to
tell "the rest of the story."

Code 539 -- 60 Caps -- $28.50
(Each 500 mg.; 85% polymannans)
'Similar product' correspondence
--- Availability ---

ost people are aware of the beneficial effects of aloe vera -- in soothing burns topically, aiding digestion, etc. Few are aware of modern discoveries concerning one powerful group of polysaccharides called "polymannans."
Mannans are the mortar that hold the building blocks of the immune system together, aiding macrophages and other components of immune response to "recognize" invasive agents. Without these complex glyconutrients, the immune system operates blindly -- something akin to driving a car while blindfolded. Stripped of their ability to recognize pathogenic bacteria, viruses, molds, and other micro-organisms, your own cells will allow these invaders to operate and reproduce freely, creating an internal environment that set the stage for a host of disease conditions. (The documents assembled with links below provide considerable depth for those who want to know what we've managed to uncover over the last 20 years.)

Most of the crucial pioneering research in this area was conducted by Carrington Laboratories of Irving, Texas. One reliable source has told us that Carrington has spent well over $50 million (though larger numbers are out there) in research on the medicinal effects of various glyconutrient fractions of the aloe plant. To date, the largest outlet for Carrington's products has been an MLM (multi-level marketing) company in the U.S. called Mannatech Incorporated. We cannot think of a single disease that, at some point, one of the legends of Mannatech distributors out there has not called or emailed us about -- saying that a Mannatech product was the definitive cure.
Do not fault Mannatech. (Our experience with network marketing and pyramid schemes, in general, is that if they care health care products, expect to see a strong propensity for curative exaggerations in the field -- a fact frequently cited by any of a number of state attorney general offices in the U.S. tasked with consumer protection. And then there are the outrageous markups necessary to sustain opulent marketing plans rich enough to attract an effective sales force... but that's another article.) This is not the same as saying that many of the beneficial claims of those consumable products with lower chain mannans are not substantive -- (though any claim of exclusivity most decidedly is). We wouldn't have investigated this thoroughly if the science behind this emerging field of nutrition (one of relatively recent development) was not solid.
However, like all facets of the nutraceutical world, this is an instance where the devil is in the details. Most of the products made in the world of aloe extracts involve either spray drying or freeze drying. A gentler method that would ensure that more of the long and "extra long" acemannans are left intact, thereby avoiding heat lability issues, would be low temperature dehydration. The problem is expense if you're trying to produce a cheap product for the network marketing industry. Since we don't have this burden, we opted to work with colleagues of Dr. Siegel, which makes it this way.


In addition to low temperature dehydration, Aloe Vera Acemannan is guaranteed to contain at least 85% polymannans, with not less than 25 to 35% the extra long chain acemannans, the premium aloe polymannan nutrients. It is extracted from aloe barbadensis miller, the aloe plant shown to have one of the highest levels of polymannan content. The only ingredient in this product is aloe vera gel powder, 200:1. (For an alternative protocol to bypassing the "first pass" phenomenon and getting as much as possible from this product, see the inset statement at the bottom of the right column. Also, for those who many have read about 1,000:1 or other riduculous extraction claims, read our customer response).
If you have any questions about this premium product, please email us.

1. What is Aloe? -- This Word file provides an overview of the nutritional components of aloe vera, with special emphasis on aloe polymannans -- broken down into short chain, medium chain, large chain, and very large chain. Discusses what polymannans do in the body and why these nutrients have been disappearing from our diet in the industrial age.
   
2. Aloe's Growing Acceptance -- A short, three page Word file that discusses the increased acceptance of aloe vera, particularly on account of our better understanding of the effects of polymannans. These include immunomodulation effects and the anti-viral effects of acemannans -- with mention of the inhibition of HIV infection of lymphoblasts and the selective binding of HIV infected cells.
   
3. U.S. Patent No. 5,786,342 -- A clear leader in the research of mannans is Carrington Laboratories of Irving, Texas. (They have been the principal supplier to Mannatech, a popular multi-level marketing company in the U.S.) This patent, filed in June, 1995, and issued in July, 1998, discusses the known medicinal effects of acemannans in its corpus.
   
4. Effects of aloe vera preparations on the human bioavailability of Vitamins C and E. This study, conducted at the University of Scranton (Scranton, Pennsylvania, USA), demonstrates how the inner gel fraction of the whole leaf (which would contain acemannans) effected a substantial increase in the bioavailability of vitamins A and C in the subjects tested. Be sure to view the tables at the end of this four page paper.
   
5. Compliments Using Mannose -- This interesting graphic shows how protein enzymes in the blood called Compliments orchestrate immune system responses. Compliments coat invasive agents with mannose containing molecules so phagocytes can engulf them.
   
6. Aloe, Immunity, and Health Care -- This is the third page of the July, 2001 issue of "Inside Aloe," put out by International Aloe Science Council, Inc. Of particular value is the content, expressed in clear layman's terms, of the value of mannan glycoproteins (GP), which help the body identify "nearly all dangerous micro organisms," and the nature of their signal structure.
7. The biological activities of mannans and related complex carbohydrates (Doc, 9 pages) -- This study was conducted at Texas A & M University and probably funded by Carrington Laboratories. The study's abstract says it all: "Complex polymers containing mannose (mannans) possess significant biological activity when administered to mammals. When given orally, they inhibit cholesterol absorption and induce hypocholesterolemia. If administered by other routes, they bind to mannose-binding proteins and induce macrophage activation and interleukin-l release, inhibit viral replication, stimulate bone marrow activity, promote' wound healing, and inhibit tumor growth. This range of activities makes the mannans potentially important biological-response modifiers and therapeutic agents."
8. The Importance of Harvesting and Manufacturing Premier Aloe Vera -- This document like many of the links on this page were provided by colleagues and associates of Dr. R. Siegel, M.D., one of the foremost authorities on aloe research and the medicinal properties of its diverse nutrients. The dehydrate powder sited in this document is what you are purchasing from Alpha Omega Labs.
9. Aloe: The Source of Master Glyconutrient -- Dr. H. Reginald McDaniel (M.D.), like Dr. R. Siegel, is another pioneer in the field of aloe glyconutrients. This paper is a technical read, but it contains a level of depth on the importance of mannans in human physiology not contained in other documents. Despite being only slightly over a page in length, it gives both a chronological overview of what has happened since initial discoveries were made in the mid-80's through accepted principles now in vogue in the early 21st century. Among its elucidating points: (1) "Cell relationships from attraction of the sperm to the egg, embryological growth development and differentiation, cell adhesion, defense, healing, and programmed cell death with regeneration (apoptosis), is regulated by a sugar-coding domain in activator molecules." (2) "The medical and scientific community is now rapidly accepting the power of dietary sugars low or absent in the modern diet, to support restoration of health." (3) As always, the corrupt influence of the pharmaceutical industry to short-circuit advances in this field and the dissemination of both product and the knowledge behind it. On this same line of thinking is a two-page overview by Dr. R. Siegel on The Science of Immunity and The Regulation of Immunity.
10. Natural Plant Molecules -- Mannans are critical to immuno-function. This five-page paper, with ample footnoted references, provides technical descriptions of their mechanisms of action. A good primer on the subject for those who will appreciate the technical detail.
11. Innate Immune Mechanisms: Non-Self Recognition -- Abstract: "The innate immune system contains a range of cell-bound and soluble proteins which eliminate pathogens by recognizing unique molecular patterns expressed by microorganisms, but not by host cells. Alternatively, host cells express proteins that protect them from attack by the alternative pathway of complement activation whereas foreign organisms lack these protective proteins and are, therefore, susceptible to complement attack." This twelve page, 1999 paper was written by Christopher R. Parish with Australian National University and is a good primer on the critical importance of recognition molecules.
12. Carbohydrate Research Headlines -- This is a good four-page summary of findings up to the 2001-2002 time frame; however, the contents are largely covered in other links above. Check out the graphic on inflammatory protein disposal and the role of mannans in the process on page two.
13. Inside A White Blood Cell -- Excellent graphic demonstrating the the effects of mannan deficiency and the mechanics behind mannose assistance in producing the right enzymes necessary for the immune system's white blood cells to do their assigned job.

Take one to two capsules per day. A method for taking this product that we feel is optimal is described in the right column.

The long chain acemannans in our Aloe Vera Acemannan are undoubtedly central to a banned, intravenously administered aloe extract product in the U.S. called Albarin -- made using a special freeze dried process developed by Ivan Danhof, M.D., and celebrated among alternative cancer therapy proponents.
On October 11, 2001, 120 agents of the U.S. Food & Drug Administration, Florida Department of Law Enforcement, and Hillsborough County Sheriff's Office conducted raids on Florida clinics using Albarin -- clinics run by nutritionist, Joe di Stefano. (See video: Cancer and Albarin: Alternative Treatment? (11/28/01).) This event is now a cause celebre, widely reported by alternative health care and civil liberty organizations, ranging from Life Extension and American Freedom Press. Incidentally, despite the fact that the FDA could not find fault sufficient to file charges, that didn't stop money-hungry plaintiffs' attorneys from putting out the word that they were looking for potential clients.
The reports of strong anti-viral and anti-cancer properties of Albarin dovetail with our understanding of its mechanisms of action. (See hepatitis-C with anti-cancer abilities.)
Does Albarin cure cancer? If you ask the hundreds of users who have had been successfully treated, they will tell you, "Absolutely." Without access to patient records, we will tell you that we simply do not know -- (although it has been reported that the first 100 patients Danhof used Albarin on came from a hospice, where they had been told they only had two to three months to live -- and 94 of these patients were saved, a remarkable success rate for terminal cancer patients.)
What we WILL tell you is that the suppression of Albarin fits the very same pattern we've seen with cancerolytic herbs, underscoring the motivations that prevent the cancer industry from allowing any real, effective treatment to be made public. (Keep in mind that Florida oncologists felt very threatened. After all, Albarin treatment at The Medical Center for Preventative and Nutritional Medicine was running just $1,100 for the complete program, from initial visit to remission -- about 25 treatments. This is equal to about one week's worth of chemotherapy. How could the cancer industry afford to let this success get out of the bag and damage oncologists' income?)
What we will ALSO tell you if that if you read the research behind polymannans (see links at bottom of left column), we believe you will be able to connect the dots for yourself -- as we have.
And this is infinitely better than allowing the political powers that be to connect the dots for you.

Getting Around "First Pass" ... Then "Die-Off" First of all, if you do not understand the principle of "first pass," please read our introduction in the natural suppository section. To get the most out of this product, we recommend that you take two capsules and break each of them open, spilling the contents into a small cup. Then use a small spoon to mix this powder with one Tsp. (15 ml.) of water or your favorite juice. Instead of immediately swallowing the mix, which at this point will have a somewhat light, gel-like consistency, drink it and hold it under your tongue (sublingually) for about one minute before swallowing. The taste of Aloe Vera Acemannan is somewhat "herby" and slightly bitter, but with the flavor of the juice, it is well masked. Promise. Last of all: Users of this product often note a mild headache and/or slight nausea after initially using this product. This "die-off" effect, known for its flu-like symptoms, is the body's response to an overload of dying pathogenic micro-organisms created by a newly alerted immune system. The symptoms soon pass.